The Race for Diagnosis of Polycystic Ovary Syndrome (2024)

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Geralyn Lambert-Messerlian

Department of Pathology and Laboratory Medicine, Women and Infants Hospital and the Alpert Medical School at Brown University

,

Providence, RI 02903

,

USA

Department of Obstetrics and Gynecology, Women and Infants Hospital and the Alpert Medical School at Brown University

,

Providence, RI 02903

,

USA

Correspondence: Geralyn Lambert-Messerlian, PhD, Women and Infants Hospital and the Alpert Medical School at Brown University, 70 Elm Street, 2nd floor, Providence, RI 02903, USA. Email: gmesserlian@wihri.org.

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The Journal of Clinical Endocrinology & Metabolism, dgae495, https://doi.org/10.1210/clinem/dgae495

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26 July 2024

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Polycystic ovary syndrome (PCOS) is a recognized risk factor for the long-term health of women. PCOS is not only a challenge for reproductive health; it conveys lifelong risks for diabetes, dyslipidemia, hypertension, obstructive sleep apnea, endometrial cancer, and cardiovascular disease, among other morbidities (1). These increased risks persist even when controlling for high body mass index, a common feature of PCOS, and most apply across premenopausal and postmenopausal women. The health consequences are exacerbated by missed or late diagnoses, which are common. One provocative study showed that it often took more than 2 years and 3 different health care providers for women to receive a diagnosis of PCOS, regardless of residing in North America, Europe, or other parts of the world (2).

An ongoing challenge in diagnosing PCOS and understanding its prevalence has been the lack of uniformity in clinical criteria (3). The National Institutes of Health (NIH), in 1990, was first to introduce diagnostic criteria for PCOS. A Rotterdam expert consensus (2003) then expanded the definition and later, the Androgen Excess and PCOS Society (2006) proposed a modification. Currently, the NIH evidence-based workshop (2012) recommends diagnosis by 2 of 3 criteria: ovulatory dysfunction, biochemical or clinical hyperandrogenism, and/or polycystic ovary morphology. Patients are categorized into 1 of 4 PCOS phenotypes based on the clinical findings.

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    • Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study

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The Race for Diagnosis of Polycystic Ovary Syndrome (2024)

FAQs

Which race is most affected by PCOS? ›

Hispanic women with PCOS have the most severe phenotype, both in terms of hyperandrogenism and metabolic criteria. Non-Hispanic Black women have an overall milder polycystic ovarian syndrome phenotype than Hispanics and in some respects, than Non-Hispanic White women.

What is the diagnosis of polycystic ovary syndrome? ›

To receive a diagnosis of PCOS, you must meet two of the following criteria: irregular ovulation, which is usually indicated by an irregular menstrual cycle or a lack of a cycle. signs of increased androgen levels or a blood test confirming you have increased levels. multiple small cysts on the ovaries.

Who is most likely to get PCOS? ›

Women and people AFAB can get PCOS any time after puberty. Most people are diagnosed in their 20s or 30s when they're trying to get pregnant. You may have a higher chance of getting PCOS if you have obesity or if other people in your biological family have PCOS.

What percentage of people have polycystic ovary syndrome? ›

Polycystic ovary syndrome (PCOS) affects an estimated 8–13% of reproductive-aged women. Up to 70% of affected women remain undiagnosed worldwide. PCOS is the commonest cause of anovulation and a leading cause of infertility.

Which country has the highest rate of PCOS? ›

The age-standardised annual incidence rate of PCOS also varied substantially by country. In 2019, Kuwait [108.6 (95% UI: 71.7 to 151.4)], Qatar [105.1 (95% UI: 68.0 to 147.9)] and Saudi Arabia [103.0 (95% UI: 66.9 to 143.0)] had the highest age-standardised annual incidence rates.

What age group is most affected by PCOS? ›

Who gets PCOS? Between 5% and 10% of women between 15 and 44, or during the years you can have children, have PCOS. Most women find out they have PCOS in their 20s and 30s, when they have problems getting pregnant and see their doctor. But PCOS can happen at any age after puberty.

What does a PCOS belly look like? ›

PCOS belly can look different from typical weight gain. It commonly resembles a protruding stomach, and you may find that most of your weight gain accumulates in this area.

Are people with PCOS more likely to have a boy or girl? ›

Results: No significant difference in sex ratio was detected between PCOS and controls, even if it resulted significantly different in the full-blown and non-PCO phenotypes.

What is the life expectancy of a person with PCOS? ›

Women with PCOS lose a year of life

The mean follow-up time was 13.1 years in both groups, during which 1,003 controls and 177 women with PCOS died. The mean age at death was 51.4 years for the PCOS group versus 52.6 years for the control women, a significant difference (P < . 001).

Are you born with PCOS or do you develop it? ›

You are born with PCOS, but symptoms often start during puberty although for some people this can be later, up to their early twenties. There are lots of different symptoms that can be caused by PCOS.

What triggers PCOS? ›

Because the symptoms of PCOS tend to run in families, the syndrome is probably caused, at least in part, by a change, or mutation, in one or more genes. Recent research conducted in animal models suggests that in some cases PCOS may be caused by genetic or chemical changes that occur in the womb.

Can PCOS go away with weight loss? ›

Lifestyle changes

Weight loss of just 5% can lead to a significant improvement in PCOS. You can find out whether you're a healthy weight by calculating your body mass index (BMI), which is a measurement of your weight in relation to your height. A normal BMI is between 18.5 and 24.9.

What race does PCOS affect the most? ›

The prevalence of diagnosed PCOS varied by race/ethnicity and was 1.6% among white women but ranged as high as 3.5% among South Asian women and as low as 1.1% among Chinese women (Table 1). The prevalence among Hispanic and Black women was 1.9% and 1.7%, respectively.

Is PCOS a disability? ›

PCOS by itself is very unlikely to qualify you for Social Security Disability (SSD) benefits. However, the Social Security Administration (SSA) does take the combine affects of multiple medical conditions into account when evaluating disability claims.

What are PCOS prone to? ›

Women with polycystic ovary syndrome (PCOS) are at higher risk for several other health conditions, some of them serious.
  • Insulin Resistance. ...
  • Metabolic Syndrome. ...
  • Type 2 Diabetes. ...
  • Obesity. ...
  • Heart Disease and High Blood Pressure (Cardiovascular Disease) ...
  • Obstructive Sleep Apnea. ...
  • Mood Disorders. ...
  • Inflammation.
Sep 29, 2022

Why is PCOS becoming more common? ›

At the 2023 Endocrine Society International meeting, the rise in numbers was confirmed. “Another determinant can be there is more awareness as to clinical signs and symptoms and appropriate workups in countries where PCOS was not so readily diagnosed [in the past] due to a lack of resources,” says Dr.

What is the color for PCOS? ›

World PCOS Day is September 1 and marks the start of PCOS Awareness Month. If you see an abundance of teal in September, note that it is the awareness color for the condition.

Do people with PCOS get sick more? ›

conducted a population-based study in England and reported that the crude COVID-19 incidence among 21,292 women with PCOS was 18.1, whereas this rate was 11.9 per 1.000 persons/year among 78,310 women without PCOS after age and body mass adjustment. Adjusting women with PCOS were found to have an increased risk of 28%.

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